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Книга ISBN13 9783659151880 - Design and Development of Extended Release Tablet of Nicotinic acid (Brijeshkumar Chaudhari,Mukesh Patel and Natvarlal Patel) в магазинах, библиотеках и электронных библиотеках с он-лайн чтением

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Название: Design and Development of Extended Release Tablet of Nicotinic acid
Nicotinic acid (NA) as lipid lowering agent drug has not become a first-line treatment due to the strong side effect called flushing occurs when given in immediate release dosage form. The tablets were prepared by wet granulation method using HPMC K-15M, polymer as retardant and the prepared tablets of NA will remain intact up to 2 hrs in pH 1.2 due to Eudragit L 100-55 and its release is not only initiated but tact fully retarded up to 12 hrs and were found to be superior in physical properties,dissolution characteristics, and drug content uniformity. The drug release from the matrix tablet Fitted to the Higuchi model and Zero order release which indicates non-Fickian diffusion.N8 showed good similarity with theoretical profile of nicotinic acid. Excipients has significant effect on drug release,because DCP retarded the release due to hydrophobic nature, on the contrary MCC increased drug release for its swelling property and causing burst release, and lactose moderately affected...
Авторы: Brijeshkumar Chaudhari,Mukesh Patel and Natvarlal Patel
Издательство: LAP Lambert Academic Publishing
Год: 2012
Местонахождение: OZON.ru
ISBN: 9783659151880


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10 января 2015 года: Запуск базы ISBN10 и ISBN13

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